TUBE ADDITIVE STOPPER COLOR SAMPLE COMMENT
None Red Serum Clotting requires at least 30 minutes
at room temperature
Silica clot activator Red/black Serum Silica speeds the clotting
process compared to no
activator
Thrombin Gray/yellow Serum Speeds clotting process
significantly
to produce serum in
several minutes
— used mostly
for urgent (STAT)
testing
Lithium Heparin Green Plasma Preferred plasma sample for
most chemistry tests — not
suitable when
testing for lithium
Sodium Heparin Green Plasma Used when testing for lithium—
not
suitable when testing for
sodium
EDTA Lavender Plasma Occasionally used for some
chemistry tests and typically
used for
Hematology
Potassium EDTA
in
special plastic tube Tan or brown Plasma For blood lead testing;
tubes are certified to have very low levels of
contamination by lead
Sodium fluoride/
potassium
oxalate Gray Plasma For glucose testing — sodium
fluoride inhibits metabolism of
glucose by white blood cells
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